Dura Substitute Market: Introduction

According to the report, the global dura substitute market was valued at US$ 175.6 Mn in 2020 and is projected to expand at a CAGR of 5.9% from 2021 to 2031. Dural substitute is a medical device used in surgeries to repair dura mater, the outermost layer that covers and protects the brain. Animal collagen or nanofibers woven together with an elastic material to form a soft tamponade can also be used to create a dural substitute.

Dural substitutes are required to prevent CSF leaks and to allow dural openings to heal after surgery. Dural substitutes can be biological or synthetic, harvested from animals or human cadavers, and used as an onlay or suturable grafts. The key advantage of using a dural substitute is that it is similar to the patient's dura and can absorb and integrate into the host tissue.

Increase in need of neurosurgery due to rise in the number of road accidents and sports injuries is a major factor boosting the growth of the global market. However, product recalls is anticipated to hamper the growth of the market.

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Increase in Popularity of Biomimetic-synthetic-absorbable Dural Graft among Medical Professionals

Dural repair materials are transitioning from animal tissue-derived materials to synthetic materials, as well as from inert to absorbable properties. Biomimetic patch is a new dural repair product that provides functional properties similar to alternate therapies. The biomimetic patch has another three-dimensional nonwoven microfiber structure that is both mechanically strong and biocompatible. The biomimetic structure and proper rate of degradation of the new absorbable dura replacement can lead to significant regeneration of the dura mater, thereby providing a novel method to dural defect repair. Redura manufactured by Medprin is an example of biomimetic patch that is FDA-approved degradable material made up of poly-L-lactic acid (PLA).

Biological Grafts Segment to Lead Dura Substitute Market

In terms of material, the global dura substitute market has been bifurcated biological graft and synthetic graft. The biological graft segment has been split into autografts, allografts, and xenografts. The synthetic segment has been segregated into polytetrafluoroethylene and others. Biological grafts are manufactured by bioengineering tissues from various animals such as cows (bovine pericardium) and pigs (porcine intestinal sub mucosal layer). These materials are rich in collagen fibers and have a low tendency to induce immunological responses. Favorable mechanical properties for suturability and desirable resorption properties for tissue remodelling are often mutually incompatible in biologically derived dura replacements. Many biologic grafts have the benefit of being fully reformed, in which the graft's natural components (e.g., collagen) recruit cell infiltration and angiogenesis, which engage in the graft material's restructuring.

Autografts, allograft, or xenografts, and commercially processed graft material derived from bovine collagen sources or human cadaveric tissues are options for the repair of dural defects.

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Neurosurgery to Dominate Global Dura Substitute Market

Based on application, the global dura substitute market has been classified into neurosurgery and spinal surgery. The neurosurgery segment held major share of the market in 2020. Dural repair after craniotomy is a popular treatment outcome in neurosurgery. Dural closure is particularly important after surgeries in the posterior fossa or skull base, where the risk of CSF leak is significant. This augments the demand for dura substitutes in neurosurgical procedures. Dural substitutes are used for different neurosurgeries such as cranial reconstruction, tumor removal - all craniotomies, skull base, neurovascular procedures, posterior fossa decompressions, etc. The dura substitute are routinely used in neurosurgical procedures hence by application neurosurgery segment is held major segment of market during forecast period.

Hospitals to be Major End-user

In terms of end-user, the global dura substitute market has been divided into hospitals, ambulatory surgical centers, and others. The hospitals segment held major market share in 2020. The growth of the segment can be ascribed to increase in hospitalization of patients for spine and cranial surgeries and rise in the use of dura substitutes for dural repair. The most common types of neurosurgery procedures performed in hospitals include craniotomy, chiari decompression, and spinal fusion. Rise in the rate of hospitalization for duraplasty procedures is anticipated to drive the segment during the forecast period

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North America to Lead Global Dura Substitute Market

In terms of region, the global dura substitute market has been segmented into North America, Europe, Latin America, Asia Pacific, and Middle East & Africa. North America dominated the global dura substitute market in 2020, accounting for 41.8% share. Developed healthcare infrastructure and presence of patient specific healthcare systems are factors fueling the growth of the dura substitute market in North America.

The U.S. dominated the market in North America due to rapid adoption of new technologies for soft tissue repair, presence of key players, and higher penetration of research activities across the country. Moreover, rise in burden of neurosurgical diseases is leading to increase in cranial and spinal duraplasty, which, in turn, is likely to boost the demand for dura substitute in North America.

Competition Landscape

The global dura substitute market is fragmented due to presence of large number of leading players. Key players operating in the global market include Cook Medical LLC, B. Braun Melsungen AG, Integra LifeSciences, Cousin Surgery, W. L. Gore & Associates, Inc., Biosynth Lifesciences, Acera Surgical, Inc., Medprin, Medtronic, Stryker, DePuy Synthes, Gunze Limited, Baxter, Bennett Health, Inc., RTI Surgical, and Natus Medical Incorporated.

  • Dura Substitute Market, by Application
    • Neurosurgery
    • Spinal Surgery
  • Dura Substitute Market, by End-user
    • Hospitals
    • Ambulatory Surgical Centers
    • Others

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