Vaccine Adjuvants Market is projected to grow from USD 1.5 billion in 2022 to USD 1.6 billion by 2027, at a CAGR of 1.7% from 2022 to 2027, according to a new report by MarketsandMarkets™. The growth of the market is projected to be driven by collaborations and partnerships among market players for the development of vaccine adjuvants, an increasing number of COVID-19 vaccines in the development pipeline and increasing focus on immunization programs.


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Key Market Players

Key players in the vaccine adjuvants market include GSK plc (UK), Dynavax Technologies (US), Novavax (US), Agenus Inc. (US), Croda International plc (UK), Seppic (France), OZ Biosciences (US), Phibro Animal Health Corporation (US), Associated British Foods plc (UK), InvivoGen (US), Merck KGaA (Germany), CSL Limited (Australia), Vertellus (US), Allergy Therapeutics (UK), Riboxx GmbH (Germany), CaPtivatϵ Pharmaceuticals LLC (US), EuBiologics Co., Ltd. (South Korea), Pacific GeneTech Limited (US), Hawaii Biotech Inc. (US), and Vaxine Pty Ltd. (Australia).

Vaccine Adjuvants Market Dynamics

Drivers: Rising prevalence of infectious diseases

The prevalence of infectious diseases, such as influenza, tuberculosis, malaria, and HIV, among others, has increased. The WHO estimates that seasonal influenza results in ~3 to 5 million cases of severe illness and ~290,000 to 650,000 respiratory deaths each year. In this regard, national influenza centers (NICs) and other national influenza laboratories from 74 countries have reported that the Global Influenza Surveillance and Response System (GISRS) laboratories tested more than 204,655 specimens for influenza between January 20, 2020, and February 20, 2020. Of these specimens, ~29% were found to be positive for the influenza virus. Influenza is one of the most common infectious diseases in the US.

Restraints: Skepticism about animal-sourced vaccine adjuvants and limitations on shark fishing

Squalene, derived from shark liver oil, is used in some adjuvants. This has led to the overfishing of sharks. As per the conservationist group Shark Allies, nearly 250,000 sharks need to be killed for the development of one COVID-19 vaccine dose for the global population.

Opportunities: Rising funding for vaccines and infectious disease research activities

With the emergence of COVID-19, government authorities and pharmaceutical & biotechnology companies have recognized the importance of research on infectious diseases.    In June 2022, the US announced a funding of USD 122 million to top Indian medical research institutes to prevent avoidable epidemics, early detection of disease threats, and rapid and effective response.

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Challenges: Side effects and high toxicity of adjuvants

Vaccine adjuvants have various limitations, such as side effects and high toxicity, which are the major challenges hindering market growth. For instance, aluminum-based adjuvants have mild reactions after injection. Frequent occurrence of granulomas results in an increase in IgE production, and high levels of these salts cause neurological disorders and dialysis-associated dementia.

The Asia Pacific region is the fastest-growing region of the vaccine adjuvants market

The Asia Pacific is estimated to be the fastest-growing segment of the market. The growth of the vaccine adjuvants markets of the region is drive by increasing investments in the life sciences sector and rising awareness through conferences & symposiums, and growing emphasis on strategic initiatives such as partnerships, and collaborations by biopharma and biotech companies.

Recent Developments

  • Dynavax Technologies (US) entered into a fully funded collaboration with the US Department of Defense to conduct a Phase 2 clinical trial for a plague vaccine adjuvanted with CpG 1018.
  • SK Bioscience (South Korea)and GSK plc (UK)entered into a collaboration for COVID-19 vaccine development.

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