Respiratory effects of oral mitragynine and oxycodone in a rodent model. Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans. #Kratom #Mitragynine #Oxycodone #Safety #Respiratorydepression #Rat #Animalmodel #Pharmacokinetics #Pharmacodynamics #Opioidepidemic #research #study https://kratomlords.com/kratom-research/respiratory-effects-mitragynine-oxycodone/

atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical atai and Kures are poised to address two key factors underlying the opioid epidemic developing a potentially safer and more widely available alternative for both pain management and opioid maintenance therapy. One of the leading therapeutic indicators of kratom is its analgesic effect. One study of Kratom users in Malaysia showed that 90% were using kratom as a substitute for opioids, with 84% reporting that kratom eased their opioid withdrawal symptoms. #7hydroxymitragynine #atai #kratom #KratomEffects #opioids #alternative #KratomResearch #KratomStudy #kratomtrial #mitragynaspeciosa #pharmaceutical #WhatisKratom https://kratomlords.com/kratom-research/atai-life-sciences-phase-1-trial-kratom-derived-pharmaceutical/

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Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://www.medlegal360.com/opioid-lawsuits/ When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits

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Natural herb Kratom may have therapeutic effects Using results of a survey of more than 2,700 self-reported users of the herbal supplement kratom, sold online and in smoke shops around the U.S., Johns Hopkins Medicine researchers conclude that the psychoactive compound somewhat similar to opioids likely has a lower rate of harm than prescription opioids for treating pain, anxiety, depression and addiction. In a report on the findings, published in the Feb. 3 issue of Drug and Alcohol Dependence, the researchers caution that while self-reporting surveys aren’t always entirely reliable, they confirmed that kratom is not regulated or approved by the U.S. Food and Drug Administration (FDA), and that scientific studies have not been done to formally establish safety and benefits. They say that U.S. drug agencies should seek to study and regulate rather than ban kratom sales outright because of its seemingly safe therapeutic potential, and as a possible alternative to opioid use. Read More https://kratomlords.com/kratom-news/natural-herb-kratom-may-have-therapeutic-effects/ #kratom #wearekratom #herbs #kratomlegality #kratomnews