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  • Respiratory effects of oral mitragynine and oxycodone in a rodent model.

    Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids

    Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans.

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    Respiratory effects of oral mitragynine and oxycodone in a rodent model. Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating effects of opioids Consistent with mitragynine’s pharmacology that includes partial µ-opioid receptor agonism with little recruitment of the respiratory depressant activating β-arrestin pathway, mitragynine produced no evidence of respiratory depression at doses many times higher than known to be taken by humans. #Kratom #Mitragynine #Oxycodone #Safety #Respiratorydepression #Rat #Animalmodel #Pharmacokinetics #Pharmacodynamics #Opioidepidemic #research #study https://kratomlords.com/kratom-research/respiratory-effects-mitragynine-oxycodone/
    KRATOMLORDS.COM
    Respiratory effects of oral mitragynine and oxycodone
    Compare the respiratory effects of oral mitragynine to oral oxycodone in rats for evaluating the respiratory effects of opioids
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  • atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical

    atai and Kures are poised to address two key factors underlying the opioid epidemic developing a potentially safer and more widely available alternative for both pain management and opioid maintenance therapy.

    One of the leading therapeutic indicators of kratom is its analgesic effect. One study of Kratom users in Malaysia showed that 90% were using kratom as a substitute for opioids, with 84% reporting that kratom eased their opioid withdrawal symptoms.

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    atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical atai and Kures are poised to address two key factors underlying the opioid epidemic developing a potentially safer and more widely available alternative for both pain management and opioid maintenance therapy. One of the leading therapeutic indicators of kratom is its analgesic effect. One study of Kratom users in Malaysia showed that 90% were using kratom as a substitute for opioids, with 84% reporting that kratom eased their opioid withdrawal symptoms. #7hydroxymitragynine #atai #kratom #KratomEffects #opioids #alternative #KratomResearch #KratomStudy #kratomtrial #mitragynaspeciosa #pharmaceutical #WhatisKratom https://kratomlords.com/kratom-research/atai-life-sciences-phase-1-trial-kratom-derived-pharmaceutical/
    KRATOMLORDS.COM
    atai Life Sciences - Phase 1 trial of kratom-derived pharmaceutical
    A pharmaceutical from atai Life Sciences (ATAI) based on a component found in kratom led to pain-relieving effects in an early-stage trial.
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://medlegal360.medium.com/opioid-lawsuits-can-we-put-an-end-to-the-opioid-crisis-4e9fcece29e9
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://medlegal360.medium.com/opioid-lawsuits-can-we-put-an-end-to-the-opioid-crisis-4e9fcece29e9 When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://joyrulez.com/blogs/102090/Opioid-Lawsuits-Can-we-put-an-end-to-the-opioid
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://joyrulez.com/blogs/102090/Opioid-Lawsuits-Can-we-put-an-end-to-the-opioid When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
    JOYRULEZ.COM
    Opioid Lawsuits: Can we put an end to the opioid crisis?
    https://www.medlegal360.com/opioid-lawsuits/ The opioid epidemic is nothing more than opioid addiction. When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began...
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://www.zupyak.com/p/3118396/t/opioid-lawsuits-can-we-put-an-end-to-the-opioid-crisis
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://www.zupyak.com/p/3118396/t/opioid-lawsuits-can-we-put-an-end-to-the-opioid-crisis When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
    WWW.ZUPYAK.COM
    Opioid Lawsuits: Can we put an end to the opioid crisis?
    com/opioid-lawsuits/The opioid epidemic is nothing more than opioid addiction. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans and opioid lawsuits were filed then to harness the opioid deaths. Purdue Pharma, owned by the Sacklers, declared bankruptcy in 2019 after facing approximately 3000 opioid lawsuits stemming from Oxycontin's adverse side effects. McKinsey & Company, a consulting firm to various governments and corporations, was sued for promoting the sale of Purdue Pharma's Oxycontin and indirectly contributing to the opioid epidemic. Pharmaceutical companies are refusing to accept full responsibility, claiming that the illicit black-market sale of opioid pills also contributed to the opioid epidemic.
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://www.debwan.com/blogs/415939/Opioid-Lawsuits-Can-we-put-an-end-to-the-opioid
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://www.debwan.com/blogs/415939/Opioid-Lawsuits-Can-we-put-an-end-to-the-opioid When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://medlegal360.blogspot.com/2022/05/opioid-lawsuits-can-we-put-end-to.html
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://medlegal360.blogspot.com/2022/05/opioid-lawsuits-can-we-put-end-to.html When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
    Opioid Lawsuits: Can we put an end to the opioid crisis?
      https://www.medlegal360.com/opioid-lawsuits/ The opioid epidemic is nothing more than opioid addiction. When more people around the worl...
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  • Opioid Lawsuits: Is it high time to bridle the opioid crisis?
    https://www.medlegal360.com/opioid-lawsuits/
    When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives
    Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis? https://www.medlegal360.com/opioid-lawsuits/ When more people around the world become addicted to opioids, it is considered a crisis that is slowly taking millions of lives. The authorities became aware of the epidemic when it began wreaking havoc on the lives of Americans. Opioid lawsuits are a necessity in order to contain the devastation caused by opioid overdose. Until now, over 3,000 opioid lawsuits have been filed in the United States. Since opioid overdoses have claimed over a million lives in the United States alone, opioid litigations have become necessary to tame the opioid crisis, which is still claiming lives Opioidlawsuits
    Opioid Lawsuits: Is it high time to bridle the opioid crisis?
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  • Natural herb Kratom may have therapeutic effects

    Using results of a survey of more than 2,700 self-reported users of the herbal supplement kratom, sold online and in smoke shops around the U.S., Johns Hopkins Medicine researchers conclude that the psychoactive compound somewhat similar to opioids likely has a lower rate of harm than prescription opioids for treating pain, anxiety, depression and addiction.

    In a report on the findings, published in the Feb. 3 issue of Drug and Alcohol Dependence, the researchers caution that while self-reporting surveys aren’t always entirely reliable, they confirmed that kratom is not regulated or approved by the U.S. Food and Drug Administration (FDA), and that scientific studies have not been done to formally establish safety and benefits. They say that U.S. drug agencies should seek to study and regulate rather than ban kratom sales outright because of its seemingly safe therapeutic potential, and as a possible alternative to opioid use.

    Read More
    https://kratomlords.com/kratom-news/natural-herb-kratom-may-have-therapeutic-effects/
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    Natural herb Kratom may have therapeutic effects Using results of a survey of more than 2,700 self-reported users of the herbal supplement kratom, sold online and in smoke shops around the U.S., Johns Hopkins Medicine researchers conclude that the psychoactive compound somewhat similar to opioids likely has a lower rate of harm than prescription opioids for treating pain, anxiety, depression and addiction. In a report on the findings, published in the Feb. 3 issue of Drug and Alcohol Dependence, the researchers caution that while self-reporting surveys aren’t always entirely reliable, they confirmed that kratom is not regulated or approved by the U.S. Food and Drug Administration (FDA), and that scientific studies have not been done to formally establish safety and benefits. They say that U.S. drug agencies should seek to study and regulate rather than ban kratom sales outright because of its seemingly safe therapeutic potential, and as a possible alternative to opioid use. Read More https://kratomlords.com/kratom-news/natural-herb-kratom-may-have-therapeutic-effects/ #kratom #wearekratom #herbs #kratomlegality #kratomnews
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