By addressing obesity and conditions like polyphagia and Prader-Willi syndrome that result in an insatiable appetite, vibrating weight loss pills have the potential to completely transform the way that weight loss is approached.

Vibrating weight loss pills are creating tides in weight loss management research. According to the Centers for Disease Control and Prevention (CDC), over two thirds of adult Americans are overweight, and over forty percent are obese, according to their most recent data. During COVID-19, the United States' obesity rate continued to rise, rising by 3% between March 2020 and March 2021.

Massachusetts Institute of Technology (MIT) conducted the research on the vibrating weight loss pill. The National Science Foundation, Novo Nordisk, the MIT Department of Mechanical Engineering, a Schmidt Science Fellowship, and the National Institutes of Health all provided funding for the study.

The primary goal of this groundbreaking study and experiment was to treat obesity and overeating issues without the negative effects that come with using weight loss medications and undergoing surgery.

Unlike traditional weight-loss pills that rely on chemical interactions, the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill operates on the principle of a bioelectronic device. The Vibrating Ingestible BioElectronic Stimulator (VIBES) pill is a capsule measuring 30.65 millimeters in length, with a gelatinous membrane covering it. The tiny silver oxide battery inside the vibrating weight loss pill dissolves the gelatinous membrane when it reaches the stomach due to the stomach acid. After the electrical circuit is finished, the vibrating motor is turned on and vibrates for an average of 38.3 minutes.

It is recommended to take the VIBES pill 20 to 30 minutes before eating, on an empty stomach. The motor beeps at frequencies intended to trigger the stomach wall's sensory nerves, which typically respond to tissue stretching.

Through luminal vibratory stimulation, the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill activates mechanoreceptors and stroke mucosal receptors, facilitating the release of serotonin. Vibrating Ingestible BioElectronic Stimulator (VIBES) pill activates mechanoreceptors and stroke mucosal receptors through luminal vibratory stimulation, which helps release serotonin and initiates a hormonal metabolic response appropriate for a fed state.